Acute Hepatitis B Follow Up
Reporting Name
Overview
Follow up of patient with newly confirmed hepatitis B infection.
Useful For
Determining if patient with acute hepatitis B progressed to chronic hepatitis B infection.
Profile Information
| Acute Unknown Hepatitis Screen | Available separately | Always performed |
| Components | ||
| HBsAg | NO | YES |
| HBsAg Neutralization | NO | NO |
| Anti-HBs | YES | YES |
| Anti-HBc Total Ab | NO | YES |
Reflex Tests
| Reporting Name | Available separately | Always performed |
| HBsAg Confirmation (neutralization) | NO | NO* |
* Autoreflex of HBsAg-reactive to HBsAg Neutralization Confirmation
Testing Algorithm
Specimens submitted for Acute hepatitis B follow up will be tested for hepatitis B surface antigen with autoreflex neutralization confirmation (HBsAg); hepatitis B surface antibody (Anti-HBs); hepatitis B core total antibodies.
Indications for Testing
Newly diagnosed acute hepatitis B infection requires follow up in 3 – 6 months to determine if patient spontaneously cleared HBV infection or progressed to chronic infection that may require treatment.
Clinical Information
HBsAg is a hallmark of HBV infection and appears in the serum during the incubation period, usually 1 – 10 weeks after exposure and 2 – 7 weeks before the onset of symptoms. Approximately 95% of patients have detectable HBsAg at the onset of jaundice. Most patients who recover from HBV infection clear HBsAg within 6 months, and persistence of HBsAg in serum beyond this time implies chronicinfection.
Reference Values
NONREACTIVE
Interpretation
Special instructions link (Hepatitis Interpretive)
Clinical Reference
Curry, M. P., and Chopra, S. 2010. Acute Viral Hepatitis, p. 1577-1592. In Mandell, D., Bennett, J. E., and Dolin, R. Principles and practice of infectious diseases, 7th ed., vol. 2. Churchill Livingstone, Elsevier, Philadelphia, PA.
Latest Updates
Respiratory Testing Memorandum 2023
Jan 1
Guidance for Mpox Laboratory Testing July 7th, 2023
Jan 1