Acute Hepatitis B Follow Up
Follow up of patient with newly confirmed hepatitis B infection.
Determining if patient with acute hepatitis B progressed to chronic hepatitis B infection.
|Acute Unknown Hepatitis Screen||Available separately||Always performed|
|Anti-HBc Total Ab||NO||YES|
|Reporting Name||Available separately||Always performed|
|HBsAg Confirmation (neutralization)||NO||NO*|
* Autoreflex of HBsAg-reactive to HBsAg Neutralization Confirmation
Specimens submitted for Acute hepatitis B follow up will be tested for hepatitis B surface antigen with autoreflex neutralization confirmation (HBsAg); hepatitis B surface antibody (Anti-HBs); hepatitis B core total antibodies.
Indications for Testing
Newly diagnosed acute hepatitis B infection requires follow up in 3 – 6 months to determine if patient spontaneously cleared HBV infection or progressed to chronic infection that may require treatment.
HBsAg is a hallmark of HBV infection and appears in the serum during the incubation period, usually 1 – 10 weeks after exposure and 2 – 7 weeks before the onset of symptoms. Approximately 95% of patients have detectable HBsAg at the onset of jaundice. Most patients who recover from HBV infection clear HBsAg within 6 months, and persistence of HBsAg in serum beyond this time implies chronicinfection.
Special instructions link (Hepatitis Interpretive)
Curry, M. P., and Chopra, S. 2010. Acute Viral Hepatitis, p. 1577-1592. In Mandell, D., Bennett, J. E., and Dolin, R. Principles and practice of infectious diseases, 7th ed., vol. 2. Churchill Livingstone, Elsevier, Philadelphia, PA.